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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

Fig. 7

Chimeric Rec/Np9/env proteins potentially encoded by HERV-K111, the Venter locus and locus chr4p16.1b_K-*. a Amino acid sequences of proteins potentially encoded by spliced env gene transcripts of HERV-K111 and the Venter locus are aligned to the canonical Env protein sequence of locus chr7p22.1_K-6 (=HERV-K(HML-2.HOM); Genbank accession number AF074086; ref. [89]). Note that only the N-terminal 60 aa and the C-terminal 99 aa of chr7p22.1_K-6 Env protein are shown, with both alignment blocks separated by a dashed line. b Chimeric Env/Rec/Np9 protein potentially encoded by a spliced transcript from locus chr4p16.1b_K-* multiply aligned with Env/Rec and Np9 protein sequences as encoded by loci chr7p22.1_K-6 (aa 1–87 are shown) and chr1p31.1_K-1. Previously described functional domains within Rec and Np9 are indicated. Differences between protein sequences are highlighted. Dot matrix comparisons below the alignment further depict sequence similarities of respective proteins. Parameters of sequence comparisons were as follows: window size: 5; Min. % score: 50; Hash Value = 1; pam250 scoring matrix

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