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Table 2 Relative cloning frequencies and locus origins of cDNA sequences from an env gene 5′ region*

From: Transcriptional profiling of HERV-K(HML-2) in amyotrophic lateral sclerosis and potential implications for expression of HML-2 proteins

locus designation ALS Ctrl Type Env Rec/Np9 hg19
motor motor motor sc motor motor sc
89-Mot 62-Mot 64-Mot 802-SC 1509-Mot 73-Mot 4263-SC
chr1p31.1_K-1     4.00 7.69   4.00 1 606 Np9 chr1:75844857
chr1q23.3_K-18     4.00     1 553   chr1:160667241
chr3q12.3_K-5 62.50 77.50 70.00 28.00 53.85 40.00 40.00 1 263 Np9 chr3:101412824
chr3q13.2_K-3 6.25 2.50    7.69 6.67 4.00 1 434 Np9 chr3:112750203
chr3q21.2_K-4       13.33   2   Rec chr3:125611223
chr5q33.3_K-10     8.00     1    chr5:156091809
chr11q23.3_K-20       6.67   1 431   chr11:118594283
chr19q11_K-19       6.67   2 699   chr19:28131235
Venter   7.50 10.00 28.00 15.38   20.00 1 452   
chr1:155…/chr5:156… 31.25 12.50 20.00 24.00 15.38 13.33 32.00     
chr8:80…/chr8:12…     4.00   13.33      
# cDNA sequences 16 40 10 25 13 15 25     
  1. *A total of 4 samples from ALS patients and 3 samples from controls were examined. A number of cDNA sequences could not be assigned with confidence to either one of two different HML-2 loci on chr1:155,598,877–155,599,165 or chr5:156,087,137–156,087,425, and chr8:8,061,161–8,061,741 or locus chr8:12,318,971–12,319,551. Note that the skew towards type 1 loci is caused by lower amounts of RT-PCR product from type 2 loci and therefore relatively few clones with type 2-derived PCR-product (see the main paper text). See also legends to Tables 1 and 2 for more details