Locus designation |
np9
|
rec
| Type | Rec/Np9 | hg19 |
---|
ALS | ctrl | ALS | ctrl |
---|
motor | motor | sc | sc | sc | sc | motor | motor | sc | sc | sc | motor | sc |
---|
32-Mot | 35-Mot | 357-SC | 5847-SC | 802-SC | 5458-SC | 32-Mot | 35-Mot | 357-SC | 5847-SC | 802-SC | 23-Mot | 5458-SC |
---|
chr3q12.3_K-5 | 98 | 5 | 88 | 86 | 15 |
33
| 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | Np9 | chr3:101412824 |
chr3q21.2_K-4 | 0 |
16(*)
|
0
|
14
|
0
|
4(*)
|
0
|
0
|
0
|
0
|
0
|
0
|
25
| 2 | Rec | chr3:125611223 |
chr5q15_K-31 | 0 | 0 | 0 | 0 | 0 | 0 | 100 | 100 | 100 | 100 | 100 | 100 | 75 | “2” | | chr5:92793228 |
chr22q11.21_K-24 | 0 | 0 | 0 | 0 | 8 | 4 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | Np9 | chr22:18934451 |
Venter | 0 | 68 | 0 | 0 | 0 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | | |
HERV-K111 | 2 | 11 | 0 | 0 | 46 | 17 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | | |
ambiguous | 0 | 0 | 12 | 0 | 31 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | | | |
# cDNA sequences | 64 | 19 | 17 | 7 | 13 | 24 | 16 | 18 | 2 | 1 | 3 | 23 | 4 | | | |
- *A total of 7 different ALS-derived and control samples were investigated. Percentages of cDNA sequences assignable to specific HML-2 loci are given. Relative cloning frequencies are separated into np9 and rec-typical lengths. Total numbers of cDNA clones per sample are given in the bottom line. A number of sequences among the np9 cDNA sequences could not be assigned with certainty to specific HML-2 loci in the human reference genome or non-reference HML-2 sequences and were therefore categorized as “ambiguous”. Note that a number of cDNA sequences isolated from sample #35 and assignable to HML-2 type 2 locus chr3q21.2_K-4 appeared as alternatively spliced transcripts of an np9-typical length. The same was true for a cDNA sequence isolated from sample 5458-SC and assignable to locus chr3q21.2_K-4. See Table 1 for the three rightmost columns