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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia

Fig. 3

Bioinformatic analysis reveals PU.1 as a highly connected hub protein involved in innate and adaptive immunity. a STRING protein-protein interaction network of the top 102 differentially expressed genes specific to mixed glial cultures with PU.1 knockdown implicates PU.1 as a central regulator of altered genes. b Gene ontology analysis demonstrating that PU.1-regulated genes are involved in innate and adaptive immune biological processes. c The majority of PU.1 regulated genes are localized to the extracellular region, MHCII complexes, or aspects of various endocytic pathways. d Molecular functions involved in antigen presentation and actin filament binding were altered by PU.1 silencing

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