Fig. 7
From: PU.1 regulates Alzheimer’s disease-associated genes in primary human microglia
Schematic identifying the contribution of PU.1 to microglial processes. Microglia contain several cell surface receptors implicated in the recognition of various antigenic matter including stressed-but-viable neurons, bacterial and viral pathogens, and misfolded proteins including Aβ1–42. PU.1 silencing in microglia attenuated the expression of receptors involved in phagocytic recognition (TREM2, DAP12, FCGR3A, MRC1, and CLEC7A), antigen processing (CD74, CTSS, and CYBB), and antigen presentation (HLA-DMB, HLA-DPA1, HLA-DQA1, HLA-DQB1, and HLA-DRA) and can be pharmacologically reduced by vorinostat. FCγR = Fc gamma receptor, TCR = T-cell receptor