Fig. 5

Pre-treatment with local neutralisation of C1q and assessment of retina at day 14 (a). b Pre-treatment with ANX-M1 anti-C1q antibody prior to the start of photo-oxidative damage (PD, day 0) showed no significant change in the number of TUNEL⁺ cells at day 14, versus IgG control (P > 0.05). c There was no difference in outer nuclear layer (ONL) thickness observed between ANX-M1 anti-C1q antibody and IgG control (P > 0.05). d Minimal effect was observed in the number of IBA1⁺ microglia/macrophages between two cohorts (P > 0.05). e-g Pre-treatment with local inhibition of classical complement did not decrease the retinal function as observed in a-wave (e), b-wave response characteristics (f) and mean amplitudes at 1.9 log cd.s/m² (g) (P > 0.05). h No change in the cone response was also observed between mice treated with ANX-M1 anti-C1q antibody and IgG control (P > 0.05). Statistical analyses were determined by an unpaired student t-test or two-way ANOVA followed by post-hoc multiple comparison (NS denotes no significance)