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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: The Trem2 R47H Alzheimer’s risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans

Fig. 4

Aberrant splicing of Trem2 variants containing the R47H mutation with and without additional mutations used to create three different R47H ki mice. a The minigene construct used to investigate exon1/2 splicing of the Trem2 variants shown in (b). b Sequence alignment of Trem2 variants investigated for aberrant splicing. c Exon 1/2 splicing of mouse Trem2 variants described in (b). d Exon 1/2 splicing of human TREM2 variants described in (b). Note that only mouse transcripts undergo aberrant splicing. EV: empty vector

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Molecular Neurodegeneration

ISSN: 1750-1326