Fig. 1

Minor alterations in expression of lysosomal and autophagy-related genes in brain of Grn^−/− mice. a mRNA expression for 45 selected genes associated with the lysosome-autophagy degradation pathway [45, 46] in brain of Grn^+/+ (wt) and Grn^−/− (ko) mice at 6 and 12 months of age (for original data see Additional file 2). Genes are grouped by their function within these pathways or by their FTLD-association. Previously identified TFEB targets are labeled by red boxes [46, 47]. N = 3 mice per group, notice the low expression differences between individual mice and between 6- and 12-month-old mice. Trem2 and Atp6v0d2 were below the detection limit. b Fold change of gene expression which show at least one significand change either at 6 or 12 months of age. Data were normalized to the corresponding mean value of Grn^+/+ (wt) mice and are shown as mean ± SD. For statistical analysis the unpaired, two-tailed student’s t-test was used (n = 3) (*, p < 0.05; **, p < 0.01; ***, p < 0.001)