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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Early lysosomal maturation deficits in microglia triggers enhanced lysosomal activity in other brain cells of progranulin knockout mice

Fig. 8

Schematic summary of differential effects of PGRN deficiency on brain cell types. Lysosomal impairment in microglia observed in young Grn−/− mice result in enhanced lysosomal activity in non-microglial brain cells like neurons in aged Grn−/− mice. Basal lysosomal functions of microglia and neurons are indicated in orange, changes to lower activity (yellow) in microglia or higher activity (red) in neurons or other non-microglial brain cells are caused by PGRN deficiency and aging

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Molecular Neurodegeneration

ISSN: 1750-1326