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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Deep proteomic network analysis of Alzheimer’s disease brain reveals alterations in RNA binding proteins and RNA splicing associated with disease

Fig. 2

Enrichment of AD Genetic Risk Factors within TMT-LysC Network Modules. Enrichment of proteins contained within genetic regions identified by genome wide association studies (GWAS) as risk factors for AD, autism spectrum disorder, and schizophrenia was calculated for each module in the TMT-LysC network. Modules highlighted in dark red were significantly enriched for AD risk factors, and not for risk factors associated with autism or schizophrenia. The horizontal dotted line indicates a z-score level of enrichment of 1.96, or FDR < 0.05, above which enrichment was considered significant

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Molecular Neurodegeneration

ISSN: 1750-1326