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Fig. 6 | Molecular Neurodegeneration

Fig. 6

From: Modifying Rap1-signalling by targeting Pde6δ is neuroprotective in models of Alzheimer’s disease

Fig. 6

hAPP deficit in spike frequency adaptation is rescued by REM. a Dendritic firing rate of hippocampal CA1 pyramidal neurons in WT and hAPP slices in response to increasing depolarising step current injections (50–450 pA; n = 12 mice per genotype; repeated measures two-way ANOVA: Interaction: P = 0.0006; DF = 8; F(8,176) = 3.649; Sidak’s multiple comparison: 400 pA: P = 0.0218; t = 3.069; DF = 198; 450 pA: P = 0.0071; t = 3.41; DF = 189). b Dendritic firing rate of hippocampal CA1 pyramidal neurons in WT and hAPP slices perfused with either vehicle or 2 μM REM in response to depolarising step current step injections (50–450 pA). (Vehicle: n = 12 mice; REM: n = 15 mice; repeated measures two-way ANOVA: Interaction: P < 0.0001; DF = 8; F(8,200) = 5.082; Sidak’s multiple comparison: 400 pA: P = 0.0168; t = 3.146; DF = 225; 450 pA: P = 0.0079; t = 3.372; DF = 225). Note that the overall firing rates were increased in the second experiment (b) compared to the first one (a). This is likely due to the addition of the vehicle DMSO which was shown previously to enhance neuronal activity [60, 61]. c Dendritic AHP amplitude in CA1 neurons in response to the first depolarising current that induced an AP in hAPP slices with or without REM (Vehicle: n = 12 mice; REM: n = 16 mice; P = 0.0128; t = 2.673; DF = 26)

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