Table 2 Aβ-specific T cell subsets regulate AD pathogenesis in experimental models
From: Peripheral immune system in aging and Alzheimer’s disease
Subset | Location | AD Model | Specificity | Effects on pathogenesis | Reference |
|---|---|---|---|---|---|
TH1 | Parenchyma | APP/PS1 | Aβ | Adoptively transferred cells increased microglia activation and Aβ deposition | [117] |
TH1 | Parenchyma | J20 with Aβ peptide vaccination | Aβ | Migrated to Aβ plaques with increased clearance, while inducing transient meningoencephalitis | [126] |
TH1 | Parenchyma | APP/PS1 | Aβ | Cells injected to cerebrospinal ventricle migrated to Aβ plaques, increased Aβ clearance and promote neurogenesis | [127] |
TH2 | Outside the brain | APP/PS1 | Aβ | Adoptively transferred cells improved working memory, decreased microgliosis and reduced plasma cytokines. No effect on plaque load inside the parenchyma but reduced vascular amyloidosis | [128] |