Fig. 2
From: Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology
Deregulated miRNAs are expressed in neurons. Fluorescent in situ hybridization of 5 deregulated miRNAs combined with a nuclear counterstain (DAPI) and immunofluorescence for activated astrocytes (GFAP) in 10 M APPtg mice. A) All miRNA probes (rows) demonstrate high expression in hippocampal neuronal layers, except for the scrambled probe. Scale bar, 50 μm. A’) higher magnification of the yellow box indicated in A, demonstrating little expression of miRNA ISH probes in GFAP-positive cells. Scale bar, 100 μm