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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Deregulation of neuronal miRNAs induced by amyloid-β or TAU pathology

Fig. 4

miRNA overexpression does not induce robust cognitive deficits in WT mice. a) Outline of behavioral study. Male mice (C57BL/6 J, 18–26 weeks ol, n = 9–12 per treatment group) were stereotactically implanted with an intracerebroventricular guide cannula and injected 1× per week with either a miR-mimic to overexpress individual miRNAs (3wk scheme), a mix of 6 miR-mimics (miR-mix; 7wk scheme) or negative control oligonucleotide (Ctrl). b) Mean fold change (SEM) compared to equimolar control oligonucleotide of miRNAs in the hippocampus after individual miRNA or miR-mix overexpression. c-e) Overexpression of individual miRNAs does not induce changes in cued or contextual conditioned fear responses. f) Path length in the MWM to find the submerged platform over 10 training days. MiR-mix treatment did not induce significant differences in learning ability. g) MiR-mix treatment does not affect cued or contextual conditioned fear response. OE: overexpression; wk.: week; OF: open field test; CFR: conditioned fear response; MWM: Morris water maze; NOR: novel object recognition test; SPSN: social preference/social novelty test

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