Fig. 2
From: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis
Loss of retinal ganglion cells and severe retinal degeneration in Nrf1-deficient RPCs. (a–f) Hematoxylin and eosin staining of retinal sections from wildtype (a, c and e) and Nrf1f/f;Six3-Cre (b, d, and f) at E16.5, P20, and 7 months old. (g, h) Eyeballs from wildtype (g) and Nrf1f/f;Six3-Cre (h) animals. The peripheral rim of underlying retinas is plotted with dotted lines. (i, j) Ventral view of the brains showing the optic nerve and optic chiasm in wildtype (i) and Nrf1f/f;Six3-Cre (j) animals. Scale bars: 50 μm. ONL: outer nuclear layer. INL: inner nuclear layer. GCL: ganglion cell layer. WT: wildtype. NBL: neural blast layer