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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis

Fig. 5

Differentiated RGCs undergo apoptosis in Nrf1f/f;Six3-Cre retina. (a, b) TUNEL assay on E14.5 wildtype (a) and Nrf1f/f;Six3-Cre (b) retinal sections. (c-e) E13.5 wildtype (e) and Nrf1f/f;Six3-Cre (d, e) sections labeled with anti-Pou4f2 and anti-cleaved caspase 3 antibodies. (e, e′ and e′′) Higher magnification images of Nrf1f/f;Six3-Cre sections labeled with anti-caspase (e) and Pou4f2 (e′) antibodies. (e′′) Merged images. Arrowheads indicate cells that are double positive for caspase and Pou4f2. Scale bars: 50 μm in a and b, 100 μm in c and d. WT: wildtype

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