Fig. 8
From: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis
Nrf1 conditional knockout by Rho-iCre causes severe photoreceptor degeneration. (a–f) H&E staining of retinal sections from wildtype (a, c, and e) and Nrf1f/f;Rho-iCre (b, d, and f) at 6 weeks, 8 weeks, and 5 months old. (g–l) Immunostaining of wildtype (g, i, and k) and Nrf1f/f;Six3-Cre (h, j, and l) retinal sections with anti-rhodopsin and anti-cone arrestin antibodies at 6 weeks, 8 weeks, and 5 months old. (m) The number of rows of photoreceptor nuclei in wildtype and Nrf1f/f;Rho-iCre. Scale bars: 20 μm. OS: outer segment. IS: inner segment. ONL: outer nuclear layer. INL: inner nuclear layer. GCL: ganglion cell layer. WT: wildtype