Table 3 Top 10 GO terms relevant to 595 upregulated genes in E13.5 Nrf1f/f; Six3-Cre retinas
From: Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis
Rank | GO Category | GO ID | GO Term | Number of Focused Genes | P Value | FDR |
|---|---|---|---|---|---|---|
1 | GOTERM_BP_FAT | GO:0007155 | cell adhesion | 70 | 1.40E-22 | 5.00E-33 |
2 | GOTERM_BP_FAT | GO:0022610 | biological adhesion | 70 | 1.60E-22 | 3.90E-33 |
3 | GOTERM_BP_FAT | GO:0042127 | regulation of cell projection | 57 | 4.80E-15 | 3.70E-31 |
4 | GOTERM_BP_FAT | GO:0001525 | angiogenesis | 23 | 2.40E-10 | 3.30E-31 |
5 | GOTERM_BP_FAT | GO:0051094 | positive regulation of developmental process | 29 | 9.60E-10 | 7.80E-31 |
6 | GOTERM_BP_FAT | GO:0007423 | sensory organ development | 31 | 1.00E-09 | 9.90E-31 |
7 | GOTERM_BP_FAT | GO:0048514 | blood vessel morphogenesis | 27 | 1.20E-09 | 1.10E-29 |
8 | GOTERM_BP_FAT | GO:0001568 | blood vessel development | 30 | 2.00E-09 | 1.10E-29 |
9 | GOTERM_BP_FAT | GO:0009611 | response to wounding | 36 | 2.10E-09 | 1.20E-28 |
10 | GOTERM_BP_FAT | GO:0001944 | vasculature development | 30 | 9.60E-09 | 1.20E-28 |
1 | GOTERM_CC_FAT | GO:0031012 | extracellular matrix | 77 | 7.30E-29 | 4.10E-26 |
2 | GOTERM_CC_FAT | GO:0005578 | proteinaceous extracellular matrix | 62 | 9.90E-27 | 2.80E-24 |
3 | GOTERM_CC_FAT | GO:0044421 | extracellular region part | 231 | 9.50E-24 | 1.80E-21 |
4 | GOTERM_CC_FAT | GO:0031982 | membrane-bounded vehicle | 206 | 5.60E-21 | 7.90E-19 |
5 | GOTERM_CC_FAT | GO:0005576 | extracellular region | 245 | 9.40E-21 | 1.10E-18 |
6 | GOTERM_CC_FAT | GO:0009986 | cell surface | 88 | 1.30E-20 | 1.20E-18 |
7 | GOTERM_CC_FAT | GO:0044420 | extracellular matrix component | 33 | 4.50E-19 | 3.70E-17 |
8 | GOTERM_CC_FAT | GO:1903561 | extracellular vesicle | 168 | 2.70E-18 | 1.90E-16 |
9 | GOTERM_CC_FAT | GO:0043230 | extracellular organelle | 168 | 3.50E-18 | 2.20E-16 |
10 | GOTERM_CC_FAT | GO:0070062 | extracellular exosome | 166 | 9.20E-18 | 5.20E-16 |
1 | GOTERM_MF_FAT | GO:0005212 | structural constituent of eye lens | 16 | 9.60E-18 | 1.10E-17 |
2 | GOTERM_MF_FAT | GO:0005515 | protein biding | 196 | 9.70E-14 | 1.60E-12 |
3 | GOTERM_MF_FAT | GO:0005178 | integrin binding | 22 | 1.20E-12 | 1.80E-11 |
4 | GOTERM_MF_FAT | GO:0005518 | collagen binding | 16 | 1.10E-10 | 4.50E-10 |
5 | GOTERM_MF_FAT | GO:0005509 | calcium ion binding | 52 | 2.60E-09 | 5.00E-09 |
6 | GOTERM_MF_FAT | GO:0005201 | extracellular matrix structural constituent | 12 | 1.90E-08 | 3.20E-08 |
7 | GOTERM_MF_FAT | GO:0008201 | heparin binding | 21 | 2.10E-08 | 6.10E-08 |
8 | GOTERM_MF_FAT | GO:0050840 | extracellular matrix binding | 10 | 6.80E-08 | 2.70E-07 |
9 | GOTERM_MF_FAT | GO:0004872 | receptor activity | 21 | 1.90E-07 | 4.00E-07 |
10 | GOTERM_MF_FAT | GO:0004714 | transmembrane receptor protein tyrosine kinase activity | 12 | 4.10E-07 | 6.10E-07 |