ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

Table 1 Cohort Description

Cohort	N	Mean Age ± SD	Female		APOEε4+
Cohort	N	Mean Age ± SD	N	%	N	%
Caucasian
Replication AD	1480	80.5 ± 8.9	892	60.27%	831	56.15%
Replication Controls	1491	81.4 ± 8.6	840	56.34%	354	23.74%
AD	2743	79.1 ± 8.5	1648	60.08%	1634	59.57%
PSP	231	74.9 ± 7.2	106	45.89%	42	18.18%
PD	855	62.7 ± 12.0	308	36.02%	248	29.01%
DLB	306	72.9 ± 8.1	69	22.55%	151	49.35%
MSA	128	66.5 ± 8.1	56	43.80%	29	22.66%
Controls	3351	80.6 ± 7.1	1844	55.03%	800	23.87%
African-American
AD	181	78.8 ± 7.5	130	71.82%	113	62.43%
Controls	331	78.4 ± 7.9	254	76.74%	110	33.23%

Table shows the total number of subjects (N), mean age ± standard deviation (SD), number and percentage of females and the frequency of the APOEε4 allele (%APOEε4+) for subjects retained for analysis. The Replication AD and control cohort is a subset of the AD and control participants in this study non-overlapping with those in Sims et al. [1]
Abbreviations: AD Alzheimer’s disease, PSP progressive supranuclear palsy, PD Parkinson’s disease, DLB dementia with Lewy bodies, MSA multiple system atrophy

ISSN: 1750-1326