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Table 2 Association Results

From: ABI3 and PLCG2 missense variants as risk factors for neurodegenerative diseases in Caucasians and African Americans

a. ABI3 rs616338

Cohort

N

Genotype Counts (TT/CT/CC)

Minor Allele Frequency

Logistic Regression

Fisher’s

 

Cases

Controls

Cases

Controls

Cases

Controls

OR

P value

95% CI

OR

P value

95% CI

Caucasian

Replication AD

1479

1491

0/47/1432

0/33/1458

0.016

0.011

1.49

0.163

0.85–2.6

1.44

0.116

0.92–2.26

AD

2742

3351

0/78/2664

0/68/3283

0.014

0.010

1.36

0.141

0.9–2.04

1.41

0.044

1.02–1.95

PSP

231

3351

0/4/227

0/68/3283

0.009

0.010

0.86

0.773

0.3–2.42

0.85

1

0.31–2.35

PD

837

3351

0/20/817

0/68/3283

0.012

0.010

1.62

0.140

0.85–3.07

1.18

0.504

0.71–1.95

DLB

306

3351

0/11/295

0/68/3283

0.018

0.010

1.78

0.121

0.86–3.68

1.79

0.097

0.94–3.4

MSA

128

3351

0/2/126

0/68/3283

0.008

0.010

0.76

0.716

0.17–3.41

0.77

1

0.19–3.15

African-American

AD

181

331

0/2/179

0/3/328

0.006

0.005

1.28

0.809

0.18–9.18

1.22

1

0.2–7.34

b. PLCG2 rs72824905

Cohort

N

Genotype Counts (GG/CG/CC)

Minor Allele Frequency

Logistic Regression

Fisher’s

 

Cases

Controls

Cases

Controls

Cases

Controls

OR

P value

95% CI

OR

P value

95% CI

Caucasain

Replication AD

1477

1487

0/19/1458

0/29/1458

0.006

0.010

0.86

0.674

0.41–1.77

0.66

0.192

0.37–1.18

AD

2738

3346

0/31/270

0/67/3279

0.006

0.010

0.58

0.052

0.33–1.01

0.56

0.008

0.37–0.86

PSP

231

3346

0/9/222

0/67/3279

0.019

0.010

1.86

0.099

0.89–3.91

1.97

0.061

0.97–3.97

PD

853

3346

0/18/835

0/67/3279

0.011

0.010

1.28

0.511

0.62–2.63

1.05

0.788

0.62–1.78

DLB

306

3346

0/2/304

0/67/3279

0.003

0.010

0.39

0.199

0.09–1.65

0.32

0.124

0.08–1.33

MSA

127

3346

0/6/121

0/67/3279

0.024

0.010

2.71

0.059

0.96–7.62

2.39

0.050

1.03–5.57

African-American

AD

180

331

0/1/179

0/0/331

0.003

0.000

NA

NA

NA

NA

0.3523

NA

  1. Results of Fisher’s exact test and multivariable logistic regression analysis, adjusted for age, sex and APOE ε4 dosage, testing for association of rs616338 and rs72824905 with disease status. In the Caucasian AD vs. control multivariable logistic regression analysis, series was also used as an additional covariate
  2. Abbreviations: OR odds ratio, CI confidence interval
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Molecular Neurodegeneration

ISSN: 1750-1326