Fig. 2

Functional analysis of the proteomic data obtained comparing data from fast versus slow progressing ALS patients. The cross-sectional analysis was based on the list of regulated proteins (FC 1.3, p value < 0.05). Pathways with a p value < 0.05 were considered significantly enriched and–plotted with a -log 10 transformed p value. Functional analysis was performed for Reactome pathways, if not otherwise specified. Only the pathways with the highest enrichment were reported among the selected redundant pathways (mostly cell cycle and mitosis (early) and RHO GTPase (late)). Significantly enriched pathways in the early stage (a), late stage (c) and in both time points (b)