Fig. 4

Human-animal model comparison of enriched pathways (a and c) and biological processes (b and d) derived from regulated proteins in each specie. a Shows the pathways and (b) the biological processes that were found enriched in both the mouse model pre-symptomatic stage and in the human ALS proteome at an early and a late disease stage respectively. c Shows the pathways and (d) the biological processes found enriched in both the mouse model symptomatic stage and the human ALS proteome at an early and late disease stage respectively. Pathways and biological processes, including translocation of GLUT4 to the plasma membrane or acute-phase response, that were found regulated in both mouse model and human plasma proteome at all time points are indicated with an asterisk (*)