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Fig. 3 | Molecular Neurodegeneration

Fig. 3

From: Functional alterations of myeloid cells during the course of Alzheimer’s disease

Fig. 3

Mature monocytes are pro-inflammatory in AD dementia while MDSCs are anti-inflammatory in prodromal AD. Isolated mature monocytes and MDSCs displayed differential inflammatory gene expression profiles. a Mature monocytes from CDR1 and CDR2/3 display increased pro-inflammatory cytokine expression via IL-6, IL-1β, and TNF. b MDSCs from CDR0.5 patients have increased anti-inflammatory IL-10 and IL-13 expression. TGFβ transcripts were increased in CDR0.5 monocytes. One-way ANOVA with Tukey’s post hoc analysis (Control n = 13–14, CDR0.5 n = 8, CDR1 n = 7, CDR2/3 n = 10). P-values are *p < 0.05, **p < 0.01, and ***p < 0.001

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