Skip to main content
Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Fig. 4

Bioinformatics analysis of DEGs. a. Venn diagram of the number of DEGs in each age group. The number of common DEGs across months is shown in the overlapping areas. Subgroups of genes shown in the diagram are subjected to KEGG pathway enrichment analysis. Enriched KEGG pathways are listed on the side and connected to the region by arrows. b. Heat map of genes involved in NF-κB signaling and cytokine-cytokine receptor interaction. The color intensity represents the log2 fold change of the expression. c. Upstream regulator analysis. Z-score heat map of upstream regulators. The color intensity represents the Z-score. d. IPA network of target genes regulated by RELA (left panel) or STAT1 (right panel). Red represents up-regulation and green represents down-regulation. The color intensity represents the level of change

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326