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Fig. 7 | Molecular Neurodegeneration

Fig. 7

From: Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model

Fig. 7

Comparison of rTg4510 microglia DEGs with human gene expression network. a. Human brain gene co-expression network was constructed using RNAseq data from 632 participants in the ROS/MAP (Methods). Cell type specificity of genes was annotated: microglia (blue), endothelial cells (red), astrocytes (cyan), neurons (yellow) and myelinating oligodendrocyte cells (magenta). Network module 5 enriched of microglial signature genes and module 9 enriched of endothelial genes are labelled. b. DEGs in rTg4510 microglia (green) at 2-, 4-, 6-, and 8-months significantly overlap with human network module 5 and 9 (based on Fisher’s exact test). The significance and strength for the overlap is shown as Q-value and odds ratio (OR). c. Connectivity of rTg4510 DEGs at 2-, 4-, 6-, and 8- months in human co-expression network. The mean connectivity of rTg4510 microglia DEGs is represented by degree of genes shown in box plot. DEGs at two months are more connected (i.e. ‘hub’ like) than those at later time points (P-value 0.02, Wilcoxen rank sum test)

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Molecular Neurodegeneration

ISSN: 1750-1326