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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: New insights into the role of TREM2 in Alzheimer’s disease

Fig. 1

TREM2 ligands, signaling and functions. Ligands binding to TREM2 induce the association of TREM2 to DAP12 through an electrostatic interaction between a conserved positively-charged lysine in TREM2 (aa186) and a negatively- charged aspartic acid residue in DAP12, generating tyrosine phosphorylation of DAP12 within its immunoreceptor tyrosine-based activation motifs (ITAMS) by Src family kinases

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