CSF sTREM2 in the A/T/N framework. Scatter plot depicting the levels of CSF sTREM2 for each of the four biomarker profiles, as defined by the A/T/N framework, coupled with clinical staging, as defined by CDR. The biomarkers groups T (tau pathology) and N (neurodegeneration) were merged in order to reduce the number of groups to compare. The CDR = 1 stage includes some biomarker profiles will low number of subjects, which precludes performing statistical analysis. They are still shown in the figure for sake of completeness. Each biomarker category is represented in a different colour: healthy controls are depicted in blue, Alzheimer’s continuum category in red, SNAP category in green, and purple depicts biomarker profiles not assigned in a specific category in the present study. The analysis reported in the main text was conducted excluding the TREM2 rare variants carriers, the P-values are reported in bold, and the number of individuals (n) per group indicated. Including these carriers (depicted in yellow) rendered similar results (P-values reported between brackets). Solid bars represent the mean and the standard deviation (SD). P-values were assessed by a one-way ANCOVA adjusted for age, followed by Bonferroni corrected post hoc pairwise comparisons. Abbreviations: A: Aβ pathology biomarker status; AD: Alzheimer’s disease; CDR: clinical dementia rating; CSF: cerebrospinal fluid; N: neurodegeneration biomarker status; SNAP: suspected non-Alzheimer’s pathology; T: tau pathology biomarker status.