CSF sTREM2 across the Alzheimer’s continuum. Scatter plot showing the levels of CSF sTREM2 in healthy controls (depicted in blue) and the different stages of the Alzheimer’s continuum (depicted in red). The main analysis was conducted excluding the TREM2 rare variants carriers, the P-values are reported in bold, and the number of individuals (n) per group indicated. Including these carriers (depicted in yellow) rendered similar results (P-values reported between brackets) P-values were assessed by a one-way ANCOVA adjusted for age, followed by Bonferroni corrected post hoc pairwise comparisons. Abbreviations: A: Aβ pathology biomarker status; AD: Alzheimer’s disease; CDR: clinical dementia rating; CSF: cerebrospinal fluid; N: neurodegeneration biomarker status; SNAP: suspected non-Alzheimer’s pathophysiology; T: tau pathology biomarker status.