Association of CSF sTREM2 and AD core CSF biomarkers. Scatter plots representing the associations of CSF sTREM2 with each of the AD CSF core biomarkers: T-tau (a), P-tau181P (b), and Aβ1-42 (c) in three different groups defined by the biomarker profile: healthy controls (blue), Alzheimer’s continuum (red) and SNAP groups (green). The solid lines indicate the regression line and the 95% confidence interval for each of the groups. The standardized regression coefficients (β) and the P-values are shown and were computed using a linear model adjusting for age, and are conducted excluding the outliers values. Including them, did not change the conclusions (see Additional file 1: Table S2). We also performed the analysis including the participants carrying a TREM2 rare variant (depicted in yellow) and the results were similar (see Additional file 1: Table S3). Abbreviations: Aβ1-42: amyloid-beta 42; T-tau: total tau; P-tau: tau phosphorylated at Threonine 181; SNAP: suspected non-Alzheimer’s pathology.