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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma

Fig. 2

RNA alternate splicing in ONH monocytes. RNA alternative splicing analysis was performed using MATS [42]. a and b Pie diagrams showing number of differentially expressed splicing events (FDR < 0.05) between ONH Monocytes Group 1 (a) and ONH Monocytes Group 2 (b) vs. PBMCs. Events were classed as either A3SS (alternate 3’ SS), A5SS (alternate 5’ SS), RI (retained introns), SE (skipped exons), or MXE (mutually exclusive exons). c Total number of DE splicing events / total number of mapped splicing events. d Percentage of DE splicing events. e Scatter plot for all genes under the GO Term: RNA splicing (GO:0006395) in ONH Monocytes Group 1 vs. PBMCs. Grey = not DE, red = DE (FDR < 0.05). DE genes at FDR < 0.01 with a log2 CPM > 5 are named. f Transcriptome plot (IGV) showing alternative splicing (skipping of exons 4, 5, and 6) of Ptprc (CD45). Black = PBMC representative samples, red = ONH monocyte representative samples

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