Fig. 7
From: Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma
Genetic ablation of CD11b (Itgam) protects from glaucoma to aged time points. a D2.Itgam−/− mice are significantly protected from glaucoma as determined by optic nerve assessment (green = NOE; no detectable glaucoma but called no or early glaucoma as some of these eyes have early gene expression changes, yellow = MOD; moderate glaucoma, red = SEV; severe glaucoma). b Agreeing with this, RGC numbers were preserved in eyes with no detectable glaucoma. Eyes with severe glaucoma had also lost their RGCs indicating that loss of CD11b did not uncouple somal and axonal degeneration. c Example optic nerves and retinas. Left shows examples of severe retinas from eyes with severe optic nerve damage (SEV) as assessed by PPD staining of the optic nerve, right shows examples of retinas with no neurodegeneration in the optic nerve (NOE graded nerves). (Soma counts, n = 6 for each condition; optic nerve analysis as assessed by PPD staining (right) n = 32 D2.Itgam+/+ 10.5 mo; 45 D2.Itgam+/+ 12 mo; 45 D2.Itgam−/− 10.5 mo; 45 D2.Itgam−/− 12 mo)