Table 2 Overview of metabolomic studies in experimental models of PD
From: Recent advances and perspectives of metabolomics-based investigations in Parkinson’s disease
Analytical platform | Models | Differential metabolites/metabolic pathways | Reference |
|---|---|---|---|
GC-MS | PQ-exposed Drosophila | Amino acids, fatty acids, carbohydrates, etc. | Shukla AK et al. [21] |
NMR, DI-ESI-MS | PQ-exposed dopaminergic cell | Pentose phosphate pathway (PPP), glycolysis, TCA cycle | Lei S et al. [98] |
NMR | MPTP-induced PD goldfish | BCAAs, alanine, myo-inositol, fatty acids, taurine, creatinine, N-acetylaspartate, (phospho)creatine, phosphatidylcholines, cholesterols, | Lu Z et al. [114] |
LC-MS | Rotenone-treated rats | Oxidizable PUFA-containing cardiolipin | Tyurina YY et al. [99] |
HPLC-ESI-MS/MS | 6-OHDA-induced rats | Phosphatidylcholine and lysophosphotidylcholine lipid | Farmer K et al. [100] |
MS-based lipidomics | α-Syn KO, α-Syn TG mice | Age-related phospholipids | Rappley I et al. [90] |
NMR, LC-MS | Mouse model of prodromal PD | Taurine and hypotaurine metabolism, bile acid biosynthesis, glycine, serine, and threonine metabolism, and citric acid cycle | Graham SF et al. [97] |
NMR, DIESI-MS | PQ -induced dopaminergic N27 cells | Glucose metabolism | Anandhan A et al. [92] |
NMR | 6-OHDA-induced rats | GABA, Glu, Gln, lactate, N-acetylaspartate, creatine, taurine, and myo-inositol. | Zheng H et al. [115] |
UPLC-QTOF-MS | MPTP-induced PD mice | Tyrosine metabolism, mitochondrial beta-oxidation of long chain saturated fatty acids, fatty acid metabolism, methionine metabolism, and sphingolipid metabolism | Li XZ et al. [116] |
UPLC-MS | α-Syn A53T TG mice | Alanine metabolism, redox and acetyl-CoA biosynthesis pathways | Chen X et la. [91] |
LC-MS | Park2 kO mice, CCCP-treated mice | Energy metabolism | Poliquin PO et al. [93] |