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Table 2 Overview of metabolomic studies in experimental models of PD

From: Recent advances and perspectives of metabolomics-based investigations in Parkinson’s disease

Analytical platform Models Differential metabolites/metabolic pathways Reference
GC-MS PQ-exposed Drosophila Amino acids, fatty acids, carbohydrates, etc. Shukla AK et al. [21]
NMR, DI-ESI-MS PQ-exposed dopaminergic cell Pentose phosphate pathway (PPP), glycolysis, TCA cycle Lei S et al. [98]
NMR MPTP-induced PD goldfish BCAAs, alanine, myo-inositol, fatty acids, taurine, creatinine, N-acetylaspartate, (phospho)creatine, phosphatidylcholines, cholesterols, Lu Z et al. [114]
LC-MS Rotenone-treated rats Oxidizable PUFA-containing cardiolipin Tyurina YY et al. [99]
HPLC-ESI-MS/MS 6-OHDA-induced rats Phosphatidylcholine and lysophosphotidylcholine lipid Farmer K et al. [100]
MS-based lipidomics α-Syn KO, α-Syn TG mice Age-related phospholipids Rappley I et al. [90]
NMR, LC-MS Mouse model of prodromal PD Taurine and hypotaurine metabolism, bile acid biosynthesis, glycine, serine, and threonine metabolism, and citric acid cycle Graham SF et al. [97]
NMR, DIESI-MS PQ -induced dopaminergic N27 cells Glucose metabolism Anandhan A et al. [92]
NMR 6-OHDA-induced rats GABA, Glu, Gln, lactate, N-acetylaspartate, creatine, taurine, and myo-inositol. Zheng H et al. [115]
UPLC-QTOF-MS MPTP-induced PD mice Tyrosine metabolism, mitochondrial beta-oxidation of long chain saturated fatty acids, fatty acid metabolism, methionine metabolism, and sphingolipid metabolism Li XZ et al. [116]
UPLC-MS α-Syn A53T TG mice Alanine metabolism, redox and acetyl-CoA biosynthesis pathways Chen X et la. [91]
LC-MS Park2 kO mice, CCCP-treated mice Energy metabolism Poliquin PO et al. [93]