Fig. 6
From: Glucose transporter 1 critically controls microglial activation through facilitating glycolysis
The effect of STF31 on microglial glucose metabolism. a Naïve B6M7 cells were treated with different concentrations of STF31 for 24 h. Glucose uptake was then conducted. n = 3, *, P < 0.05; **, P < 0.01; ***, P < 0.001, One-way ANOVA with Dunnett’s Multiple post-test. b Glucose uptake in naïve (M0), LPS + IFNγ treated and IL-4 treated microglial cells with or without 5 μM STF31 pre-treatment for 24 h. n = 3, **, P < 0.01; ***, P < 0.001, two-way ANOVA with Bonferroni post-test. c-e Representative ECAR profiles in naïve (c), LPS + IFNγ treated (d), and IL-4 treated (e) microglia with or without 5 μM STF31. f The effect of STF31 on glycolysis of M0, M(LPS + IFNγ), and M(IL-4) B6M7 microglial cells. g The effect of STF31 on glycolytic capacity of naive, LPS + IFNγ treated and IL-4 treated B6M7 cells. Mean ± SEM, n = 3 repeated experiments, *P < 0.05; **P < 0.01; ***P < 0.001