TY - JOUR AU - Outeiro, Tiago Fleming AU - Koss, David J. AU - Erskine, Daniel AU - Walker, Lauren AU - Kurzawa-Akanbi, Marzena AU - Burn, David AU - Donaghy, Paul AU - Morris, Christopher AU - Taylor, John-Paul AU - Thomas, Alan AU - Attems, Johannes AU - McKeith, Ian PY - 2019 DA - 2019/01/21 TI - Dementia with Lewy bodies: an update and outlook JO - Molecular Neurodegeneration SP - 5 VL - 14 IS - 1 AB - Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes with normal life and daily activities. Neuropathologically, DLB is characterised by the accumulation of aggregated α-synuclein protein in Lewy bodies and Lewy neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic of PD, are common in DLB patients, but are not essential for the clinical diagnosis of DLB. Since many PD patients develop dementia as disease progresses, there has been controversy about the separation of DLB from PD dementia (PDD) and consensus reports have put forward guidelines to assist clinicians in the identification and management of both syndromes. Here, we present basic concepts and definitions, based on our current understanding, that should guide the community to address open questions that will, hopefully, lead us towards improved diagnosis and novel therapeutic strategies for DLB and other synucleinopathies. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-019-0306-8 DO - 10.1186/s13024-019-0306-8 ID - Outeiro2019 ER -