Model a | Predictors | β | 95% CI | p d | R2 | ΔR2 |
---|---|---|---|---|---|---|
Model 1: age, sex and ApoE4 status only | Age | −0.251 | − 0.033, 0.002 | 0.081 | 0.128 | NA |
Sex | 0.032 | −0.234, 0.294 | 0.819 | |||
APOE ε4 | 0.232 | −0.045, 0.500 | 0.100 | |||
Models 2 b: age, sex and ApoE4 status plus one CSF biomarker | Aβ42 | −0.312 | −0.79, − 0.043 | 0.030 | 0.216 | 0.088* |
P-tau181 | −0.456 | −0.907, − 0.236 | 0.001 | 0.308 | 0.181* | |
T-tau | −0.539 | −0.783, − 0.288 | < 0.001 | 0.386 | 0.259* | |
T-tau/Aβ42 ratio | −0.415 | −4.504, − 0.735 | 0.008 | 0.257 | 0.129* | |
Models 3 c: age, sex and ApoE4 status plus two CSF biomarkers | T-tau | −0.503 | −0.784, − 0.216 | 0.001 | 0.390 | 0.004 |
+ Aβ42 | −0.075 | −0.479, 0.279 | 0.598 | |||
Aβ42 | −0.152 | −0.589, 0.182 | 0.294 | 0.325 | −0.076* | |
+ P-tau181 | −0.391 | −0.859, − 0.121 | 0.010 |