Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau

Table 4 Hierarchical linear regression examining CSF T-tau as a function of sleep measures

Model ^a	Predictors	β	95% CI	p ^c	R²	ΔR²
Model 4: age, sex and ApoE4 status only	Age	0.065	−0.016, 0.024	0.713	0.077	NA
	Sex	−0.01	− 0.310, 0.297	0.966
	ApoE4	0.262	−0.074, 0.532	0.134
Models 5 ^b: age, sex and ApoE4 status plus one sleep variable	N2 spindle density	−0.573	−0.772, − 0.224	0.001	0.361	0.284*
	SWA	−0.265	−0.494, 0.099	0.184	0.129	0.052
	WASO	−0.247	−0.408, 0.085	0.191	0.127	0.050
	SE	0.310	−0.110, 1.672	0.084	0.163	0.086
	AHI4%	−0.248	−0.185, 0.029	0.149	0.138	0.061
	AHI-all	−0.278	−0.404, 0.057	0.135	0.142	0.065
	TST in-lab	0.171	−0.082, 0.229	0.345	0.103	0.027
	TST actigraphy	−0.063	−0.178, 0.129	0.749	0.080	0.003

ISSN: 1750-1326