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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Human Interleukin-34 facilitates microglia-like cell differentiation and persistent HIV-1 infection in humanized mice

Fig. 5

Transcriptional changes in the brain tissues of CD34-NOG-hIL-34 with HIV-1 infection. a, b Alignment of reads to human genome (h19) comparing uninfected and HIV-1 infected CD34-NOG-IL-34 mice found 687 differentially expressed genes (DEG), and the pie chart (a) and the volcano plot (b) shows the proportion and fold change of upregulated and down-regulated genes, respectively. c, d Log fold change of top ranking differentially expressed human genes for uninfected vs HIV infected CD34-NOG-hIL-34 mice in human microglia and in brain. e, f Cellular pathways involving upregulated human genes (261) were related to interferon signaling, PRR and TLR signaling (e), and downregulated human genes (426) were highly associated with pathways of EIF2 signaling and oxidative phosphorylation (f). g Unmapped reads mapped to HIV-1ADA genome indicated the expression levels of different HIV-1 genes in infected mouse brain

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