TY - JOUR AU - Beltran, S. AU - Nassif, M. AU - Vicencio, E. AU - Arcos, J. AU - Labrador, L. AU - Cortes, B. I. AU - Cortez, C. AU - Bergmann, C. A. AU - Espinoza, S. AU - Hernandez, M. F. AU - Matamala, J. M. AU - Bargsted, L. AU - Matus, S. AU - Rojas-Rivera, D. AU - Bertrand, M. J. M. AU - Medinas, D. B. AU - Hetz, C. AU - Manque, P. A. AU - Woehlbier, U. PY - 2019 DA - 2019/03/27 TI - Network approach identifies Pacer as an autophagy protein involved in ALS pathogenesis JO - Molecular Neurodegeneration SP - 14 VL - 14 IS - 1 AB - Amyotrophic lateral sclerosis (ALS) is a multifactorial fatal motoneuron disease without a cure. Ten percent of ALS cases can be pointed to a clear genetic cause, while the remaining 90% is classified as sporadic. Our study was aimed to uncover new connections within the ALS network through a bioinformatic approach, by which we identified C13orf18, recently named Pacer, as a new component of the autophagic machinery and potentially involved in ALS pathogenesis. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-019-0313-9 DO - 10.1186/s13024-019-0313-9 ID - Beltran2019 ER -