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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Glial phagocytic clearance in Parkinson’s disease

Fig. 2

Phagocytic clearance dysfunction in PD neurodegeneration. a Dopaminergic terminals in the striatum are surrounded by astrocytic and microglial processes. b PD is characterized by dopaminergic neuronal death, proteinaceous accumulations positive for α-syn in the surviving neurons as well as in astrocytes, accompanied by extended gliosis and neuroinflammation. Reactive glia can phagocytize neuronal debris and released aggregated α-syn, attenuating neurodegeneration. Multiple factors can cause phagocytic clearance mistargeting or dysfunction (enhance or decrease) thus exacerbating the neurodegenerative process

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Molecular Neurodegeneration

ISSN: 1750-1326