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Fig. 2 | Molecular Neurodegeneration

Fig. 2

From: Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Fig. 2

Development of insulin resistance precedes HFD-induced exacerbation of Aβ deposition in A7-Tg mouse brains. a Soluble Aβ40 and Aβ42 levels in the cerebral cortex of 5-month-old male A7-Tg mice fed with chow (n = 9) or HFD (n = 10). b Soluble (left) and insoluble (right) Aβ40 and Aβ42 levels in the cerebral cortex of 9-month-old male A7-Tg mice fed with chow (n = 12) or HFD (n = 11). c Soluble (left) and insoluble (right) Aβ40 and Aβ42 levels in the cerebral cortex of 15-month-old female A7-Tg mice fed with chow (n = 5) or HFD (n = 6). d-g Immunohistochemical analysis of female A7-Tg mouse brains using an anti-Aβ (82E1) antibody. Representative images of the cerebral neocortex at the level of hippocampus (d), hippocampus (e) and the percentage area covered by Aβ immunoreactivity (right panels in each figure) from 15-month-old A7-Tg mice fed with chow (n = 5) or HFD (n = 6). Data from the cerebral neocortex (f) and hippocampus (g) of 18-month old A7-Tg mice fed with chow (n = 9) or HFD (n = 7) also are shown. Data are mean ± SEM. *p < 0.05, ** p < 0.01, *** p < 0.001 (unpaired t test)

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