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Fig. 5 | Molecular Neurodegeneration

Fig. 5

From: Differential effects of diet- and genetically-induced brain insulin resistance on amyloid pathology in a mouse model of Alzheimer’s disease

Fig. 5

Deletion of IRS-2 induces metabolic impairments but suppresses Aβ deposition in A7-Tg mice. a Body weight of IRS-2-deficient A7-Tg mice at 5 and 9 month of age (Irs2+/+;A7-Tg mice: n = 6; Irs2−/−;A7-Tg mice: n = 5). b Fasting blood glucose levels of 5 and 9-month-old IRS-2-deficient A7-Tg mice (Irs2+/+;A7-Tg mice: n = 6; Irs2−/−;A7-Tg mice: n = 5). c Fasting plasma insulin levels of 9-month-old IRS-2-deficient A7-Tg mice (Irs2+/+;A7-Tg mice: n = 6; Irs2−/−;A7-Tg mice: n = 5). d Soluble (left) and insoluble (right) Aβ40 and Aβ42 levels in the cerebral neocortices of 9-month-old IRS-2-deficient A7-Tg mice (Irs2+/+;A7-Tg mice: n = 12; Irs2−/−;A7-Tg mice: n = 14). e Immunohistochemical analysis (left) and morphometry of percentage Aβ-positive areas (right) of cerebral neocortices of 15-month-old IRS-2-deficient A7-Tg mice (Irs2+/+;A7-Tg mice: n = 3; Irs2−/−;A7-Tg mice: n = 4). Data are mean ± SEM. *p < 0.05, *** p < 0.001 (unpaired t test)

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