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Fig. 4 | Molecular Neurodegeneration

Fig. 4

From: Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model

Fig. 4

Scatter plots of matrix elements between two time points. Deviation of the scatterplots from the identity line is presented for the two time points in each diagram, for each group. The identity line is marked in red, while the fit through the scatter plot passing through zero is given in black. The slope of the fit, in deviation from slope = 1 for the identity line, indicates the overall increase or decrease of the z-score values from one time point to the other. The diagrams present the situation between baseline and doxycycline treatment for 8 weeks, showing the slope is always > 1 for all groups and indicating the z-score value increase upon doxycycline treatment (reflecting switch-off of human tau expression). This is particularly pronounced for the transgenic groups with slope of 1.612 and 1.614, respectively, demonstrating a strong overall z-score increase upon treatment, while the control group has only a slight deviation from identity with a slope of 1.18

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