TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

Table 5 TREM2 is similarly expressed in AD, controls and TREM2 risk variant carriers

	Overall TREM2	ENST00000373113 (canonical transcript)	ENST00000373122	ENST00000338469 (soluble TREM2)
Control vs Case	0.11	0.2	0.19	0.04^c
Control vs TREM2-carriers	0.40	0.39	0.31	0.39
Case vsTREM2-carriers	0.11	0.26	0.19	0.15
Control vs p.R47H^a	0.33	0.34	0.15	0.06
Case vs p.R47H^a	0.24	0.38	0.35	0.11
Control vs p.R62H	0.41	0.48	0.06^b	0.25
Case vs p.R62H	0.17	0.20	0.007 ^b	0.22

Table shows the p–value for the meta-analysis for Knight-ADRC, Mayo Clinic Brain Bank and Mount Sinai Brain Bank
Meta-analyses was performed using the Zscore Method
Statistical significant results with the same effect size direction are shown in red
^aData only available for Knight-ADRC and Mount Sinai Brain Bank
^bData only available for Knight-ADRC and Mayo Clinic Brain Bank
^cStatistically significant results but with different effect size directions

ISSN: 1750-1326