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Table 5 TREM2 is similarly expressed in AD, controls and TREM2 risk variant carriers

From: TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

  Overall TREM2 ENST00000373113 (canonical transcript) ENST00000373122 ENST00000338469 (soluble TREM2)
Control vs Case 0.11 0.2 0.19 0.04c
Control vs TREM2-carriers 0.40 0.39 0.31 0.39
Case vsTREM2-carriers 0.11 0.26 0.19 0.15
Control vs p.R47Ha 0.33 0.34 0.15 0.06
Case vs p.R47Ha 0.24 0.38 0.35 0.11
Control vs p.R62H 0.41 0.48 0.06b 0.25
Case vs p.R62H 0.17 0.20 0.007 b 0.22
  1. Table shows the p–value for the meta-analysis for Knight-ADRC, Mayo Clinic Brain Bank and Mount Sinai Brain Bank
  2. Meta-analyses was performed using the Zscore Method
  3. Statistical significant results with the same effect size direction are shown in red
  4. aData only available for Knight-ADRC and Mount Sinai Brain Bank
  5. bData only available for Knight-ADRC and Mayo Clinic Brain Bank
  6. cStatistically significant results but with different effect size directions