Fig. 4

Aβo-induced memory deficit is rescued by NSC-exo but not by MN-exo. a) Schematic of the experimental design. Mice were injected icv with either NSC-exo (b) or MN-exo (c) 24 h prior to ICV injection of Aβ oligomers and testing in the novel object recognition (NOR) memory test. Aβ oligomers significantly impaired memory in mice pre-treated with vehicle (PBS) or with MN-exo, but not in mice pre-treated with NSC-exo *: not significant vs. chance and p < 0.05 vs. PBS-injected control mice (χ2 and ANOVA: F = 4.138 for 2 h recall test; F = 8.460 for 24 h recall test). N = 5 mice/group