Aβo-induced suppression of long-term potentiation (LTP) in the hippocampus is abolished by ICV injection of NSC-exo but not by MN-exo. a) Schematic of the experimental design. NSC-exo, MN-exo or PBS (vehicle) were injected icv into adult mice 24 h before euthanasia. Schaffer collateral field recording of LTP (indicated as percent of baseline in the slope of fEPSPs) was performed on brain slices prepared from NSC-exo-treated mice (B) and MN-treated mice (c) in the presence of Aβ oligomers. Control mice were injected with PBS. Aβo abolished LTP in PBS treated mice and in MN-exo-treated mice but not in NSC-exo-treated mice. d) The fEPSP amplitude for the final 10 min (time points 50–60 min post high frequency stimulation) were averaged for each condition. Aβ oligomers significantly reduced LTP in brain slices from mice injected with vehicle or with MN-exo, but not in brain slices from mice treated with NSC-exo. N = 6 mice/group (2 slices per mouse). *p < 0.05 Student’s two-tailed T-test.