Fig. 7

NSC-exo, but not MN-exo, reduce synaptic vulnerability to Aβo binding in hippocampus neurons in vitro. a) Representative confocal microscope images (40X w/3.2 zoom) showing association of Aβ oligomers (2.5 μm, 30 min; 647-Aβo, red) to hippocampal neurons (βIII-tubulin, green) generated by differentiation of adult rat hippocampus NSC. Nuclei are counterstained blue with DAPI. Calibration bar = 25 μm. b) Quantification of the number of 647-Aβο puncta shown in panel A (N = 12 images acquired from 4 independent experiments). ***p < 0.001; ****p < 0.0001 one-way ANOVA (F = 18.95) followed by Tukey’s multiple comparisons test