Fig. 5
From: Endo-lysosomal dysregulations and late-onset Alzheimer’s disease: impact of genetic risk factors
Involvement of LOAD risk factors at the BBB. Transport of Aβ through endothelial transcytosis is PICALM-dependent and a major pathway for clearing Aβ from the brain. Aβ-bound ApoE and free Aβ bind the low density lipoprotein receptor-related protein 1 (LRP1) that associates with PICALM during transcytosis. CD2AP contributes in the upkeep of BBB integrity through a process hypothesized to involve its binding-partner Rac1. Endothelial CD2AP further interacts with VCAM (CD106) and ICAM-1 (CD54), affecting immune cell extravasation