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Fig. 8 | Molecular Neurodegeneration

Fig. 8

From: Synaptic and memory dysfunction induced by tau oligomers is rescued by up-regulation of the nitric oxide cascade

Fig. 8

PDE5 inhibition rescues oTau-induced reduction in pCREB and cGMP levels after the electric shock. a Immunoblots performed on hippocampi harvested at 1 min after the electric shock. b Bar graph shows that oTau significantly decreases pCREB expression, whereas a concomitant treatment with the PDE5 inhibitor 7a is capable of rescuing pCREB expression. The average ratio of p-CREB/t-CREB is displayed (one-way ANOVA: F(3,45) = 6.166; p = 0.001; Bonferroni’s post-hoc: p = 0.045 between vehicle and oTau; p = 0.002 between oTau and oTau+7a). GAPDH expression was used as a loading control. Vehicle: n = 14; oTau n = 9; oTau+7a n = 12; 7a n = 14. c Bar graph shows that oTau significantly decreases cGMP level, whereas a concomitant treatment with the PDE5 inhibitor 7a is capable of rescuing cGMP levels (one-way ANOVA: F(3,41) = 9.643; p < 0.0001; Bonferroni’s post-hoc: p < 0.0001 between vehicle and oTau and between oTau and oTau+7a). Vehicle: n = 12; oTau n = 12; oTau+7a n = 10; 7a n = 11

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