TY - JOUR AU - Bercier, Valérie AU - Hubbard, Jeffrey M. AU - Fidelin, Kevin AU - Duroure, Karine AU - Auer, Thomas O. AU - Revenu, Céline AU - Wyart, Claire AU - Del Bene, Filippo PY - 2019 DA - 2019/07/10 TI - Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities JO - Molecular Neurodegeneration SP - 27 VL - 14 IS - 1 AB - Dynactin subunit 1 is the largest subunit of the dynactin complex, an activator of the molecular motor protein complex dynein. Reduced levels of DCTN1 mRNA and protein have been found in sporadic amyotrophic lateral sclerosis (ALS) patients, and mutations have been associated with disease, but the role of this protein in disease pathogenesis is still unknown. SN - 1750-1326 UR - https://doi.org/10.1186/s13024-019-0327-3 DO - 10.1186/s13024-019-0327-3 ID - Bercier2019 ER -