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Fig. 1 | Molecular Neurodegeneration

Fig. 1

From: Dynactin1 depletion leads to neuromuscular synapse instability and functional abnormalities

Fig. 1

Dynactin1a depletion leads to proper initial development of the CaPs but impaired growth. Axonal morphology of CaP primary motor neurons in vivo at a 2dpf, and at b 6dpf visualized in confocal z-stack projections by single-cell expression of membrane-bound mnx1:lyn-GFP, with NeuronJ tracings of the axonal arbor. Quantification of the tracings for size (total cell length and projection number) and complexity (projection number by branch order) of CaPs, c showing no significant difference in size between cells of mutants and wild-type siblings at 2dpf, but d revealing that CaPs in 6dpf homozygous mutant larvae have a smaller arbor composed of fewer projections, which retain average length when compared with their wild-type siblings. All data presented as average +/− SD. (b: n cells wild-type, mutant = 9, 9; d: n cells = 11,14). Scale bar = 50 μm

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